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Article

Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.

Biochemistry - 10 Jan 2017

Mahalingan Krishna K, Baskaran Sulochanadevi, DePaoli-Roach Anna A, Roach Peter J, Hurley Thomas D

Abstract excerpt

Glycogen synthase (GS) is the rate limiting enzyme in the synthesis of glycogen. Eukaryotic GS is negatively regulated by covalent phosphorylation and allosterically activated by glucose-6-phosphate (G-6-P). To gain structural insights into the inhibited state of the enzyme, we solved the crystal structure of yGsy2-R589A/R592A to a resolution of 3.3 Å. The double mutant has an activity ratio similar to the...

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Identifiers

PMID: 27935293
DOI: 10.1021/acs.biochem.6b00884
PMCID: PMC5516924

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