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Article

Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional/environmental heat stroke.

The Journal of physiology - 1 Jul 2009

Protasi Feliciano, Paolini Cecilia, Dainese Marco

Abstract excerpt

Malignant hyperthermia (MH) and exertional/environmental heat stroke (EHS) in humans present as similar life threatening crises triggered by volatile anaesthetics and strenuous exercise and/or high temperature, respectively. Many families (70-80%) diagnosed with MH susceptibility (MHS), and a few with EHS, are linked to mutations in the gene for the ryanodine receptor type-1 (RyR1), Ca(2+) release channel of the...

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Source

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Identifiers

PMID: 19417098
DOI: 10.1113/jphysiol.2009.171967
PMCID: PMC2727019

Genes

CASQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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