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Article

Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2017

Michelucci Antonio, Paolini Cecilia, Boncompagni Simona, Canato Marta, Reggiani Carlo, Protasi Feliciano

Abstract excerpt

In humans, hyperthermic episodes can be triggered by halogenated anesthetics [malignant hyperthermia (MH) susceptibility] and by high temperature [environmental heat stroke (HS)]. Correlation between MH susceptibility and HS is supported by extensive work in mouse models that carry a mutation in ryanodine receptor type-1 (RYR1Y522S/WT) and calsequestrin-1 knockout (CASQ1-null), 2 proteins that control Ca2+...

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Source

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Identifiers

PMID: 28465322
DOI: 10.1096/fj.201601292R
PMCID: PMC5503704

Genes

CASQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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