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Article

Transcription termination factor TTF-I exhibits contrahelicase activity during DNA replication.

EMBO reports - 1 Feb 2002

Putter Vera, Grummt Friedrich

Abstract excerpt

In mammals, sequence-specific termination of DNA replication within the ribosomal RNA genes is catalyzed by a defined DNA-protein complex that includes transcription termination factor I (TTF-I). Here we show that TTF-I acts as a polar contrahelicase contrary to the intrinsic 3' -->5' helicase activity of SV40 large T antigen. The contrahelicase activity requires binding of TTF-I to its cognate recognition site...

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Identifiers

PMID: 11818337
DOI: 10.1093/embo-reports/kvf027
PMCID: PMC1083968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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