Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and environmental interaction in allergy and asthma.

The Journal of allergy and clinical immunology - 1 Dec 1999

Holgate S T

Abstract excerpt

Asthma is an inflammatory disorder of the airways involving coordinate up-regulation of T(H)2-type cytokines encoded in a cluster on chromosome 5q(31-33) on T cells and inflammatory cells. There is also a requirement for local airway susceptibility factors that, together with T(H)2 polarization, results in hyperresponsiveness, variable airflow obstruction, and, over time, remodeling of the airway wall. Asthma has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Asthma and respiratory diseases
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Environmental Pollutants

Share to Genetic Predisposition to Disease

Share to Hypersensitivity

Share to IL-33, ST2, and ILC Pathways

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 10588993
DOI: 10.1016/s0091-6749(99)70005-9
PMCID: PMC7172426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and environmental interaction in allergy and asthma.PMID 10588993Read ↗

The genetics of asthma and allergic disorders.Semantic proximity Read ↗

Genetics of allergy and asthma.Semantic proximity Read ↗

Genetic, epigenetic, and environmental factors in asthma and allergy.Semantic proximity Read ↗

Gene by environment interactions and the development of asthma and allergy.Semantic proximity Read ↗

Genetics of asthma and allergy.Semantic proximity Read ↗

Gene-environment interactions and airway disease in children.Semantic proximity Read ↗

Gene-environment interactions in the development of asthma and atopy.Semantic proximity Read ↗

Genetics of asthma and allergic diseaseSemantic proximity Read ↗

The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma.Semantic proximity Read ↗

Advances in asthma and allergy genetics in 2007.Semantic proximity Read ↗

Interactions between genes and environmental factors in asthma and atopy: new developments.Semantic proximity Read ↗

The immunopathology and genetics of asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.