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Article

Regulation of noise in the expression of a single gene.

Nature genetics - 1 May 2002

Ozbudak Ertugrul M, Thattai Mukund, Kurtser Iren, Grossman Alan D, van Oudenaarden Alexander

Abstract excerpt

Stochastic mechanisms are ubiquitous in biological systems. Biochemical reactions that involve small numbers of molecules are intrinsically noisy, being dominated by large concentration fluctuations. This intrinsic noise has been implicated in the random lysis/lysogeny decision of bacteriophage-lambda, in the loss of synchrony of circadian clocks and in the decrease of precision of cell signals. We sought to...

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PMID: 11967532
DOI: 10.1038/ng869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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