Article
Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: a randomized controlled trial.
The American journal of clinical nutrition - 1 Oct 2012
Miller Jody C, Thomson Christine D, Williams Sheila M, van Havre Nathalie, Wilkins Gerard T, Morison Ian M, Ludgate Jackie L, Skeaff C Murray
Abstract excerpt
BACKGROUND: A genetic variant at codon 200 (Pro200Leu) of the gene encoding for glutathione peroxidase 1 (GPx1), a selenium-dependent enzyme, is associated with lower enzyme activity; however, the evidence is limited to in vitro and observational studies. OBJECTIVE: The objective was to determine whether the GPx1 Pro200Leu genetic variants modify the response of whole-blood glutathione peroxidase (GPx) activity...
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