Article
Evolution in Candida albicans populations during a single passage through a mouse host.
Genetics - 1 Jul 2009
Forche Anja, Magee P T, Selmecki Anna, Berman Judith, May Georgiana
Abstract excerpt
The mechanisms and rates by which genotypic and phenotypic variation is generated in opportunistic, eukaryotic pathogens during growth in hosts are not well understood. We evaluated genomewide genetic and phenotypic evolution in Candida albicans, an opportunistic fungal pathogen of humans, during passage through a mouse host (in vivo) and during propagation in liquid culture (in vitro). We found slower population...
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