Article
Complex genetics cause and constrain fungal persistence in different parts of the mammalian body.
Genetics - 1 Nov 2022
Mullis Martin N, Ghione Caleb, Lough-Stevens Michael, Goldstein Ilan, Matsui Takeshi, Levy Sasha F, Dean Matthew D, Ehrenreich Ian M
Abstract excerpt
Determining how genetic polymorphisms enable certain fungi to persist in mammalian hosts can improve understanding of opportunistic fungal pathogenesis, a source of substantial human morbidity and mortality. We examined the genetic basis of fungal persistence in mice using a cross between a clinical isolate and the lab reference strain of the budding yeast Saccharomyces cerevisiae. Employing chromosomally encoded...
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