Article
IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.
PloS one - 1 Jan 2009
Thye Thorsten, Browne Edmund N, Chinbuah Margaret A, Gyapong John, Osei Ivy, Owusu-Dabo Ellis, Brattig Norbert W, Niemann Stefan, Rüsch-Gerdes Sabine, Horstmann Rolf D, Meyer Christian G
Abstract excerpt
Evidence from genetic association and twin studies indicates that susceptibility to tuberculosis (TB) is under genetic control. One gene implicated in susceptibility to TB is that encoding interleukin-10 (IL10). In a group of 2010 Ghanaian patients with pulmonary TB and 2346 healthy controls exposed to Mycobacterium tuberculosis, among them 129 individuals lacking a tuberculin skin test (PPD) response, we...
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