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Article

Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma.

Leukemia & lymphoma - 1 Oct 2012

Bu Rong, Bavi Prashant, Abubaker Jehad, Jehan Zeenath, Al-Haqawi Wael, Ajarim Dahish, Al-Dayel Fouad, Uddin Shahab, Al-Kuraya Khawla S

Abstract excerpt

Aberrant nuclear factor-κB (NF-κB) regulation has been observed in many hematopoietic malignancies including diffuse large B-cell lymphoma (DLBCL). Considering the potential therapeutic utility of targeting NF-κB and its key modulators, we studied genetic alterations (mutations and amplifications) in TNFAIP3 and CARD11 genes in DLBCL samples. The incidence of CARD11 and TNFAIP3 mutations was 10.7% and 4.6%,...

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Source

Identifiers

PMID: 22397314
DOI: 10.3109/10428194.2012.668286

Genes

CARD11
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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