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Article

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.

Blood - 9 Jul 2009

Fukuda Seiji, Singh Pratibha, Moh Akira, Abe Mariko, Conway Edward M, Boswell H Scott, Yamaguchi Seiji, Fu Xin-Yuan, Pelus Louis M

Abstract excerpt

Internal tandem duplication mutations in the Flt3 tyrosine kinase gene (ITD-Flt3) and overexpression of Survivin are frequently found in patients with acute myeloid leukemia (AML). We investigated whether Survivin mediates the enhanced survival of primary hematopoietic progenitor cells (HPCs) resulting from ITD-Flt3 signaling. Ectopic ITD-Flt3 mutants increased Survivin expression in Ba/F3 cells downstream of...

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Identifiers

PMID: 19411632
DOI: 10.1182/blood-2008-11-188714
PMCID: PMC2714213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.PMID 19411632Read ↗

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