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Article

Overexpression of survivin initiates hematologic malignancies in vivo.

Leukemia - 1 Nov 2010

Small S, Keerthivasan G, Huang Z, Gurbuxani S, Crispino J D

Abstract excerpt

Survivin is an inhibitor of apoptosis protein family member that has an essential role in cellular proliferation as a component of the chromosome passenger complex. Survivin is highly expressed in embryos and in proliferating adult tissues, but it is not expressed in most differentiated cells. During tumorigenesis, however, survivin expression is dramatically upregulated. Although many studies have shown that...

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Identifiers

PMID: 20882051
DOI: 10.1038/leu.2010.198
PMCID: PMC2978276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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