Article
Isolation and characterization of cytoplasmic cyclin D1 mutants.
FEBS letters - 19 May 2009
Murakami Hirokazu, Horihata Minoru, Andojo Satoru, Yoneda-Kato Noriko, Kato Jun-ya
Abstract excerpt
To elucidate the mechanism governing the subcellular distribution of cyclin D1 protein, we randomly mutagenized human cyclin D1 cDNA and isolated mutants that encode the protein predominantly located in the cytoplasm. Experiments with Leptomycin B suggested a defect in transportation from the cyt...
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