Article
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
The EMBO journal - 3 Dec 2001
Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta G F, Pagano M, Meloche S
Abstract excerpt
The activity of the cyclin-dependent kinase inhibitor p27 is controlled by its concentration and subcellular localization. However, the mechanisms that regulate its intracellular transport are poorly understood. Here we show that p27 is phosphorylated on Ser10 in vivo and that mutation of Ser10 to Ala inhibits p27 cytoplasmic relocalization in response to mitogenic stimulation. In contrast, a fraction of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.