Article
Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.
Oncogene - 12 Oct 2006
Benzeno S, Lu F, Guo M, Barbash O, Zhang F, Herman J G, Klein P S, Rustgi A, Diehl J A
Abstract excerpt
Although cyclin D1 is overexpressed in a significant number of human cancers, overexpression alone is insufficient to promote tumorigenesis. In vitro studies have revealed that inhibition of cyclin D1 nuclear export unmasks its neoplastic potential. Cyclin D1 nuclear export depends upon phosphorylation of a C-terminal residue, threonine 286, (Thr-286) which in turn promotes association with the nuclear exportin,...
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