Article
Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jan 2000
Miller M E, Cross F R
Abstract excerpt
The G(1) cyclins of budding yeast drive cell cycle initiation by different mechanisms, but the molecular basis of their specificity is unknown. Here we test the hypothesis that the functional specificity of G(1) cyclins is due to differential subcellular localization. As shown by indirect immunofluorescence and biochemical fractionation, Cln3p localization appears to be primarily nuclear, with the most obvious...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
