Article
Cytoplasmic localization of LIM-kinase 1 is directed by a short sequence within the PDZ domain.
Experimental cell research - 25 May 1998
Yang N, Higuchi O, Mizuno K
Abstract excerpt
LIM-containing protein kinase 1 (LIMK1) is a serine/threonine kinase with a structure composed of two LIM domains, a PDZ domain, and a protein kinase domain. We examined the subcellular localization of LIMK1 and its variously deleted mutants in HeLa cells by transfection with these cDNAs. Immunofluorescence analysis revealed that the full-length LIMK1 and its mutants deleted with LIM domain or protein kinase...
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