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Article

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

30 Apr 2009

Abstract excerpt

AIMS: Highly proliferative, CD34+/CD45+ fibroblasts derived from monocytic, blood-borne precursor cells play a critical role in the development of fibrosis in a murine ischaemic/reperfusion cardiomyopathy (I/RC) model. The differentiation of human monocytes into fibroblasts in vitro occurs after transendothelial migration (TEM) induced by monocyte chemoattractant protein 1 (MCP-1). Because Rho-associated kinase-1...

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PMID: 19406912
DOI: 10.1093/cvr/cvp135

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