Article
Cardiac (myo)fibroblasts modulate the migration of monocyte subsets.
Scientific reports - 3 Apr 2018
Pappritz Kathleen, Savvatis Konstantinos, Koschel Annika, Miteva Kapka, Tschöpe Carsten, Van Linthout Sophie
Abstract excerpt
Cardiac fibroblasts play an important role in the regulation of the extracellular matrix and are newly recognized as inflammatory supporter cells. Interferon (IFN)-γ is known to counteract transforming growth factor (TGF)-ß1-induced myofibroblast differentiation. This study aims at investigating in vitro how IFN-γ affects TGF-ß1-induced monocyte attraction. Therefore, C4 fibroblasts and fibroblasts obtained by...
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