Article
Conformational coupling between the active site and residues within the K(C)-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase.
Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014
Ahn Young O, Mahinthichaichan Paween, Lee Hyun Ju, Ouyang Hanlin, Kaluka Daniel, Yeh Syun-Ru, Arjona Davinia, Rousseau Denis L, Tajkhorshid Emad, Adelroth Pia, Gennis Robert B
Abstract excerpt
The respiratory chains of nearly all aerobic organisms are terminated by proton-pumping heme-copper oxygen reductases (HCOs). Previous studies have established that C-family HCOs contain a single channel for uptake from the bacterial cytoplasm of all chemical and pumped protons, and that the entrance of the K(C)-channel is a conserved glutamate in subunit III. However, the majority of the K(C)-channel is within...
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