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Article

Binding interactions with the complementary subunit of nicotinic receptors.

The Journal of biological chemistry - 8 Mar 2013

Blum Angela P, Van Arnam Ethan B, German Laurel A, Lester Henry A, Dougherty Dennis A

Abstract excerpt

The agonist-binding site of nicotinic acetylcholine receptors (nAChRs) spans an interface between two subunits of the pentameric receptor. The principal component of this binding site is contributed by an α subunit, and it binds the cationic moiety of the nicotinic pharmacophore. The other part of the pharmacophore, a hydrogen bond acceptor, has recently been shown to bind to the complementary non-α subunit via...

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Identifiers

PMID: 23349463
DOI: 10.1074/jbc.M112.439968
PMCID: PMC3591609

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