Article
An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating.
The Journal of biological chemistry - 19 Dec 2008
Gleitsman Kristin Rule, Kedrowski Sean M A, Lester Henry A, Dougherty Dennis A
Abstract excerpt
The muscle nicotinic acetylcholine receptor is a large, allosteric, ligand-gated ion channel with the subunit composition alpha2betagammadelta. Although much is now known about the structure of the binding site, relatively little is understood about how the binding event is communicated to the channel gate, causing the pore to open. Here we identify a key hydrogen bond near the binding site that is involved in...
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