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Article

Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist.

Journal of molecular biology - 15 Dec 2000

Rogers J P, Luginbühl P, Pemberton K, Harty P, Wemmer D E, Stevens R C

Abstract excerpt

alpha-Conotoxins are small disulfide-constrained peptide toxins which act as antagonists at specific subtypes of nicotinic acetylcholine receptors (nACh receptors). In this study, we analyzed the structures and activities of three mutants of alpha-conotoxin ImI, a 12 amino acid peptide active at alpha7 nACh receptors, in order to gain insight into the primary and tertiary structural requirements of neuronal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11124036
DOI: 10.1006/jmbi.2000.4247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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