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Article

Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6.

European journal of immunology - 1 May 2009

Taylor Karen, Rolfe Mark, Reynolds Natalie, Kilanowski Fiona, Pathania Uday, Clarke Dave, Yang De, Oppenheim Joost, Samuel Kay, Howie Sarah, Barran Perdita, Macmillan Derek, Campopiano Dominic, Dorin Julia

Abstract excerpt

Beta-defensins comprise a family of cationic, antimicrobial and chemoattractant peptides. The six cysteine canonical motif is retained throughout evolution and the disulphide connectivities stabilise the conserved monomer structure. A murine beta-defensin gene (Defr1) present in the main defensin cluster of C57B1/6 mice, encodes a peptide with only five of the canonical six cysteine residues. In other inbred...

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Identifiers

PMID: 19404978
DOI: 10.1002/eji.200838566
PMCID: PMC2883079

Genes

CCR6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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