Article
Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
Scientific reports - 2 Jun 2017
Sagar Divya, Singh Narendra P, Ginwala Rashida, Huang Xiaofang, Philip Ramila, Nagarkatti Mitzi, Nagarkatti Prakash, Neumann Konstantin, Ruland Jürgen, Andrews Allison M, Ramirez Servio H, Khan Zafar K, Jain Pooja
Abstract excerpt
The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we identified functions of one C-type lectin receptor, CLEC12A, in facilitating DC binding and transmigration across the...
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