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Article

Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.

Nature immunology - 1 Aug 2004

Hornef Mathias W, Pütsep Katrin, Karlsson Jenny, Refai Essam, Andersson Mats

Abstract excerpt

Antimicrobial peptides are essential effector molecules of the innate immune system. Here we describe the structure, function and diversity of cryptdin-related sequence (CRS) peptides, a large family of antimicrobial molecules. We identified the peptides as covalent dimers in mouse intestinal tissue in amounts comparable to those of Paneth cell-derived enteric alpha-defensins. CRS peptides caused rapid and potent...

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Identifiers

PMID: 15235601
DOI: 10.1038/ni1094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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