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Article

Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a).

Genes and immunity - 1 Jun 2008

del Pilar Jiménez-A M, Viriyakosol S, Walls L, Datta S K, Kirkland T, Heinsbroek S E M, Brown G, Fierer J

Abstract excerpt

Coccidioides posadasii spherules stimulate macrophages to make cytokines via TLR-2 and Dectin-1. We used formalin-killed spherules and 1,3-beta-glucan purified from spherules to stimulate elicited peritoneal macrophages and myeloid dendritic cells (mDCs) from susceptible (C57BL/6) and resistant (DBA/2) mouse strains. DBA/2 macrophages produced more TNF-alpha and IL-6 than macrophages from C57BL/6 mice, and the...

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Identifiers

PMID: 18418396
DOI: 10.1038/gene.2008.23
PMCID: PMC3681288

Genes

TNF
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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