Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evidence for functional dependency of p18Ink4c on Cdk4.

Molecular and cellular biology - 1 Aug 2004

Pei Xin-Hai, Bai Feng, Tsutsui Tateki, Kiyokawa Hiroaki, Xiong Yue

Abstract excerpt

The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and induces the growth-suppressive function of Rb family proteins. Mutations in the Cdk4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in humans and result in a wide spectrum of tumors in mice, suggesting that INK4 is a major regulator of CDK4. Mice lacking the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase 4
Share to Cyclin-Dependent Kinase Inhibitor p18

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Cyclin-Dependent Kinases

Share to Islets of Langerhans

Share to Retina

Share to S Phase

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 15254233
DOI: 10.1128/MCB.24.15.6653-6664.2004
PMCID: PMC444851

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for functional dependency of p18Ink4c on Cdk4.PMID 15254233Read ↗

Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitorsSemantic proximity Read ↗

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.Semantic proximity Read ↗

Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue SpecificitySemantic proximity Read ↗

Expression of p16Ink4a Compensates for <i>p18Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and TissuesSemantic proximity Read ↗

<i>INK4d</i>-Deficient Mice Are Fertile Despite Testicular AtrophySemantic proximity Read ↗

p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.Semantic proximity Read ↗

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.Semantic proximity Read ↗

Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice.Semantic proximity Read ↗

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Semantic proximity Read ↗

p18<sup><i>Ink4c</i></sup> and <i>Pten</i> Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle ControlSemantic proximity Read ↗

Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways.Semantic proximity Read ↗

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.