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Article

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations.

The Journal of biological chemistry - 13 Aug 2004

Alonso Alejandra del C, Mederlyova Anna, Novak Michal, Grundke-Iqbal Inge, Iqbal Khalid

Abstract excerpt

Mutations in the tau gene are known to cosegregate with the disease in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). However, the molecular mechanism by which these mutations might lead to the disease is not understood. Here, we show that four of the FTDP-17 tau mutations, R406W, V337M, G272V, and P301L, result in tau proteins that are more favorable substrates for phosphorylation...

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Identifiers

PMID: 15190058
DOI: 10.1074/jbc.M405131200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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