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Article

Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.

Scientific reports - 19 Sept 2016

Kimura Taeko, Hosokawa Tomohisa, Taoka Masato, Tsutsumi Koji, Ando Kanae, Ishiguro Koichi, Hosokawa Masato, Hasegawa Masato, Hisanaga Shin-Ichi

Abstract excerpt

Tau is hyperphosphorylated in the brains of patients with tauopathies, such as Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). However, neither the mechanism of hyperphosphorylation nor its contribution to pathogenesis is known. We applied Phos-tag SDS-PAGE, a phosphoaffinity electrophoresis, to the analysis of tau phosphorylation in vitro by Cdk5, in cultured...

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PMID: 27641626
DOI: 10.1038/srep33479
PMCID: PMC5027580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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