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IHG-2, a Mesangial Cell Gene Induced by High Glucose, Is Human gremlin

1 Apr 2000

Abstract excerpt

We used cloning in silico coupled with polymerase chain reaction to demonstrate that IHG-2 is part of the 3'-untranslated region of gremlin, a member of the DAN family of secreted proteins that antagonize the bioactivities of members of the transforming growth factor (TGF)-beta superfamily. Mesangial cell gremlin mRNA levels were induced by high glucose, cyclic mechanical strain, and TGF-beta1 in vitro, and...

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PMID: 10744662
DOI: 10.1074/jbc.275.14.9901

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