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Article

Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma.

The Journal of biological chemistry - 23 Apr 2010

Wright Tricia M, Rathmell W Kimryn

Abstract excerpt

Ror2 is an orphan receptor tyrosine kinase with expression normally restricted to early stages of development. However, emerging evidence has placed aberrantly expressed Ror2, leading to an invasive phenotype, in several cancers including renal cell carcinoma (RCC). Although Ror2 is currently identified as up-regulated in an assortment of cancers, neither the regulatory role or mechanism of action have been...

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Topics

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Hypoxia

Share to Gene Expression Regulation, Neoplastic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Receptor Tyrosine Kinase-like Orphan Receptors

Share to Transcriptional Activation

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20185829
DOI: 10.1074/jbc.M109.073924
PMCID: PMC2857057

Genes

VHL
ROR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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