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Neph-Nephrin Proteins Bind the Par3-Par6-Atypical Protein Kinase C (aPKC) Complex to Regulate Podocyte Cell Polarity

19 Jun 2008

Abstract excerpt

The kidney filter represents a unique assembly of podocyte epithelial cells that tightly enwrap the glomerular capillaries with their foot processes and the interposed slit diaphragm. So far, very little is known about the guidance cues and polarity signals required to regulate proper development and maintenance of the glomerular filtration barrier. We now identify Par3, Par6, and atypical protein kinase C (aPKC)...

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PMID: 18562307
DOI: 10.1074/jbc.m803143200

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Related research

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Research trail→

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Neph-Nephrin Proteins Bind the Par3-Par6-Atypical Protein Kinase C (aPKC) Complex to Regulate Podocyte Cell PolarityPMID 18562307Read ↗

An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit DiaphragmsSemantic proximity Read ↗

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Loss of Podocyte aPKCλ/ι Causes Polarity Defects and Nephrotic SyndromeSemantic proximity Read ↗

aPKCλ/ι and aPKCζ Contribute to Podocyte Differentiation and Glomerular MaturationSemantic proximity Read ↗

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.Semantic proximity Read ↗

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesisSemantic proximity Read ↗

The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.Semantic proximity Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

KIBRA Modulates Directional Migration of PodocytesSemantic proximity Read ↗

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