Article
A single nucleotide change affects fur-dependent regulation of sodB in H. pylori.
PloS one - 1 Jan 2009
Carpenter Beth M, Gancz Hanan, Gonzalez-Nieves Reyda P, West Abby L, Whitmire Jeannette M, Michel Sarah L J, Merrell D Scott
Abstract excerpt
Helicobacter pylori is a significant human pathogen that has adapted to survive the many stresses found within the gastric environment. Superoxide Dismutase (SodB) is an important factor that helps H. pylori combat oxidative stress. sodB was previously shown to be repressed by the Ferric Uptake Regulator (Fur) in the absence of iron (apo-Fur regulation) [1]. Herein, we show that apo regulation is not fully...
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