Article
Autoregulation of Helicobacter pylori Fur revealed by functional analysis of the iron-binding site.
Molecular microbiology - 1 Nov 2002
Delany Isabel, Spohn Gunther, Pacheco Ana-Beatriz F, Ieva Raffaele, Alaimo Cristina, Rappuoli Rino, Scarlato Vincenzo
Abstract excerpt
The ferric uptake regulator protein Fur regulates iron-dependent gene expression in bacteria. In Helicobacter pylori it has been shown to regulate iron-activated and iron-repressed genes. In this study, we show that H. pylori Fur protein regulates transcription from its own sigma 80 promoter P fur in response to iron. Footprinting analysis shows that Fur binds at three distinct operators at P fur overlapping and...
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