Article
Resistance to hydrogen peroxide in Helicobacter pylori: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated 'KatA-associated protein', KapA (HP0874).
Microbiology (Reading, England) - 1 Dec 2002
Harris Andrew G, Hinds Francis E, Beckhouse Anthony G, Kolesnikow Tassia, Hazell Stuart L
Abstract excerpt
Helicobacter pylori infection elicits an aggressive inflammatory response that the bacterium is able to resist by virtue of its well-adapted antioxidant defence mechanisms. Catalase (KatA) appears to be a key enzyme in this resistance. Upstream of katA, a low-affinity ferric uptake regulator (Fur)-box has been identified. Downstream of katA, an ORF (HP0874) with no known function has also been identified....
Topics
- Arabidopsis Proteins
- Bacterial Proteins
- Catalase
- Culture Media
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Heat-Shock Response
- Helicobacter pylori
- Hydrogen Peroxide
- Iron
- Mutation
- Oxidative Stress