Article
Random and site-specific mutagenesis of the Helicobacter pylori ferric uptake regulator provides insight into Fur structure-function relationships.
Molecular microbiology - 1 Jul 2013
Gilbreath Jeremy J, Pich Oscar Q, Benoit Stéphane L, Besold Angelique N, Cha Jeong-Heon, Maier Robert J, Michel Sarah L J, Maynard Ernest L, Merrell D Scott
Abstract excerpt
The ferric uptake regulator (Fur) of Helicobacter pylori is a global regulator that is important for colonization and survival within the gastric mucosa. H. pylori Fur is unique in its ability to activate and repress gene expression in both the iron-bound (Fe-Fur) and apo forms (apo-Fur). In the current study we combined random and site-specific mutagenesis to identify amino acid residues important for both...
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