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Article

Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity.

Development (Cambridge, England) - 1 Dec 2003

Jászai József, Reifers Frank, Picker Alexander, Langenberg Tobias, Brand Michael

Abstract excerpt

In zebrafish acerebellar (ace) embryos, because of a point mutation in fgf8, the isthmic constriction containing the midbrain-hindbrain boundary (MHB) organizer fails to form. The mutants lack cerebellar development by morphological criteria, and they appear to have an enlarged tectum, showing no obvious reduction in the tissue mass at the dorsal mesencephalic/metencephalic alar plate. To reveal the molecular...

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PMID: 14660549
DOI: 10.1242/dev.00899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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