Article
Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration.
The Journal of pathology - 1 Apr 2013
Smeets Bart, Boor Peter, Dijkman Henry, Sharma Shagun V, Jirak Peggy, Mooren Fieke, Berger Katja, Bornemann Jörg, Gelman Irwin H, Floege Jürgen, van der Vlag Johan, Wetzels Jack F M, Moeller Marcus J
Abstract excerpt
Regeneration of injured tubular cells occurs after acute tubular necrosis primarily from intrinsic renal cells. This may occur from a pre-existing intratubular stem/progenitor cell population or from any surviving proximal tubular cell. In this study, we characterize a CD24-, CD133-, and vimentin-positive subpopulation of cells scattered throughout the proximal tubule in normal human kidney. Compared to adjacent...
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