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Article

Cell cycle control in the kidney

23 Dec 2014

Abstract excerpt

Proper control of the cell cycle is mandatory during homeostasis and disease. The balance of p53 and MDM2 integrates numerous signalling pathways to regulate the cell cycle, which is executed by multiple proteins including the cyclins, cyclin kinases and cyclin kinase inhibitors. Mutations or environmental factors that affect cell cycle control can lead to inappropriate hyperplasia or cancer as well as to cell...

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PMID: 25538161
DOI: 10.1093/ndt/gfu395

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