Article
The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery.
Molecular and cellular biology - 1 Dec 2012
Bassler Jochen, Klein Isabella, Schmidt Claudia, Kallas Martina, Thomson Emma, Wagner Maria Anna, Bradatsch Bettina, Rechberger Gerald, Strohmaier Heimo, Hurt Ed, Bergler Helmut
Abstract excerpt
The nuclear export of the preribosomal 60S (pre-60S) subunit is coordinated with late steps in ribosome assembly. Here, we show that Bud20, a conserved C(2)H(2)-type zinc finger protein, is an unrecognized shuttling factor required for the efficient export of pre-60S subunits. Bud20 associates with late pre-60S particles in the nucleoplasm and accompanies them into the cytoplasm, where it is released through the...
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