Article
Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway.
Traffic (Copenhagen, Denmark) - 1 Oct 2006
Panse Vikram Govind, Kressler Dieter, Pauli Andrea, Petfalski Elisabeth, Gnädig Marén, Tollervey David, Hurt Ed
Abstract excerpt
Ribosomal precursor particles are initially assembled in the nucleolus prior to their transfer to the nucleoplasm and export to the cytoplasm. In a screen to identify thermosensitive (ts) mutants defective in the export of pre-60S ribosomal subunit, we isolated the rix16-1 mutant. In this strain, nucleolar accumulation of the Rpl25-eGFP reporter was complemented by UBA2 (a subunit of the E1 sumoylation enzyme)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
