Article
Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence.
Oncogene - 27 Nov 2008
Leikam C, Hufnagel A, Schartl M, Meierjohann S
Abstract excerpt
Contrary to malignant melanoma, nevi are a benign form of melanocytic hyperproliferation. They are frequently observed as precursor lesions of melanoma, but they also feature biochemical markers of senescence. In particular, evidence for oncogene-induced melanocyte senescence as natural means to prevent tumorigenesis has been obtained in nevi with mutated B-Raf(V600E). Here, we demonstrate that strong oncogenic...
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