Article
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.
Oncogene - 6 Nov 2008
Zhuang D, Mannava S, Grachtchouk V, Tang W-H, Patil S, Wawrzyniak J A, Berman A E, Giordano T J, Prochownik E V, Soengas M S, Nikiforov M A
Abstract excerpt
Malignant melanomas often harbor activating mutations in BRAF (V600E) or, less frequently, in NRAS (Q61R). Intriguingly, the same mutations have been detected at higher incidences in benign nevi, which are largely composed of senescent melanocytes. Overexpression of BRAF(V600E) or NRAS(Q61R) in human melanocytes in vitro has been shown to induce senescence, although via different mechanisms. How oncogene-induced...
Topics
- Cell Line, Tumor
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Progression
- Gene Deletion
- Gene Expression
- Humans
- Melanocytes
- Melanoma
- Mitogen-Activated Protein Kinase Kinases
- Neoplasm Metastasis
- Phenotype
- Phosphatidylinositol 3-Kinases