Article
Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (the Ludwigshafen Risk and Cardiovascular Health study).
BMC medical genetics - 23 Apr 2009
Lüblinghoff Nicola, Winkler Karl, Winkelmann Bernhard R, Seelhorst Ursula, Wellnitz Britta, Boehm Bernhard O, März Winfried, Hoffmann Michael M
Abstract excerpt
BACKGROUND: Heme oxygenase-1 is an inducible cytoprotective enzyme which handles oxidative stress by generating anti-oxidant bilirubin and vasodilating carbon monoxide. A (GT)n dinucleotide repeat and a -413A>T single nucleotide polymorphism have been reported in the promoter region of HMOX1 to both influence the occurrence of coronary artery disease and myocardial infarction. We sought to validate these...
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