Article
Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1.
PloS one - 1 Jan 2013
Kramer Marcel, Sponholz Christoph, Slaba Monique, Wissuwa Bianka, Claus Ralf A, Menzel Uwe, Huse Klaus, Platzer Matthias, Bauer Michael
Abstract excerpt
The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases. Most of these associations involve either release of heme or oxidative stress. Both polymorphisms are localized in the promoter region, but previously reported correlations with heme oxygenase-1 expression remain not...
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