Article
Shorter (GT)n repeats in the haem-oxygenase 1 gene promoter are associated with better mid-term survival in subjects with coronary artery disease and abnormal ejection fraction.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Dec 2021
Liang Kae-Woei, Lee Wen-Jane, Lee Wen-Lieng, Wu Jen-Pey, Sheu Wayne H-H
Abstract excerpt
BACKGROUND: Haem oxygenase (HO)-1 is a rate-limiting enzyme for degrading haem into carbon monoxide. Subjects with longer GT repeats in the HO-1 gene (HMOX1) promoter are more likely to have coronary artery disease (CAD) and cardiovascular events. METHODS: We retrospectively enrolled CAD subjects with an abnormal ejection fraction (EF) <50% from our catheterisation data (N = 670). Polymerase chain reactions were...
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