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Article

Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II.

The journal of physical chemistry. B - 25 Aug 2016

Taraphder Srabani, Maupin C Mark, Swanson Jessica M J, Voth Gregory A

Abstract excerpt

The role of protein dynamics in enzyme catalysis is one of the most highly debated topics in enzymology. The main controversy centers around what may be defined as functionally significant conformational fluctuations and how, if at all, these fluctuations couple to enzyme catalyzed events. To shed light on this debate, the conformational dynamics along the transition path surmounting the highest free energy...

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Identifiers

PMID: 27063577
DOI: 10.1021/acs.jpcb.6b02166
PMCID: PMC5003118

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