Article
A theoretical study on the detection of proton transfer pathways in some mutants of human carbonic anhydrase II.
The journal of physical chemistry. B - 30 Oct 2008
Roy Arijit, Taraphder Srabani
Abstract excerpt
Structural and kinetic studies of mutants can give much insight into the function of an enzyme. We report the detection of possible proton transfer pathways into the active site of a number of mutants of the enzyme human carbonic anhydrase II (HCA II). Using a recently developed method of path search in the protein conformational space, we identify hydrogen-bonded networks (or proton paths) that can dynamically...
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